Liquid-Based Cytology (LBC) technique used in the field of cytopathology for the examination of cells from various body sites, most commonly the cervix. This method has largely replaced the conventional Pap smear due to its enhanced accuracy and diagnostic capabilities. In LBC Liquid-Based Cytology procedure, cells are collected from the cervix using a brush or spatula, similar to the traditional Pap smear. However, instead of smearing the cells directly onto a microscope slide, they are rinsed into a vial containing a preservative liquid.

The vial is sent to a lab where the sample is processed by filtering and centrifuging to concentrate the cells, which are then spread onto a slide. This reduces obscuring materials like blood, mucus, and inflammatory cells, resulting in cleaner slides with clearer cellular morphology.

Liquid-Based Cytology technique offers higher sensitivity and specificity in detecting precancerous lesions and cervical cancer. It also allows for additional tests, such as HPV testing, from the same sample, and can be used for non-gynecological samples like urine, sputum, and fine-needle aspirates, making it a versatile diagnostic tool.

Overall, Liquid-Based Cytology technique represents a significant advancement in the early detection and prevention of cervical cancer and other diseases, offering improved sample quality, better diagnostic accuracy, and the ability to perform multiple tests from a single specimen.